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KMID : 1145120170150030377
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Asian Journal of Beauty and Cosmetology
2017 Volume.15 No. 3 p.377 ~ p.386
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Notch Signaling in Hair Follicle Development
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Bae Seung-Hee
Lee Ki-Heon
Lee In-Ho
Kim Mi-Kyung
Lee Jae-Ho
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Abstract
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Notch pathway has been known as a major signal transduction route regulating stem cell homeostasis and development in multicellular organisms including hair follicles. Many studies have represented that Notch activity is critical to determine cell fate decision during hair follicle development. Also, growing results have revealed the pivotal role of Notch signaling pathway in controlling of hair follicle stem cell fates, regulation of hair cycles and resuscitation of injured hair organs. Furthermore, in hair bulb, Notch signaling pathway regulates hair follicle stem cell differentiation. The purpose of this review is to summarize considerable recent evidences in our understanding of Notch signaling and their regulating factors in hair follicle development to maintain their hair follicle homeostasis.
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KEYWORD
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Notch, Hair follicle, Stem cell, Growth, Development
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